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ACME Laboratories Ltd.
Folive 400 mcg Capsule
Generic: 6s-5-Methyltetrahydrofolate [Bio-Active Folate]
৳৩০/ PCS
ইউনিট টাইপ নির্বাচন করুন
১
সারা বাংলাদেশে ৩-৫ দিনের মধ্যে ডেলিভারি
ভুল বা ক্ষতিগ্রস্ত পণ্যে ২৪ ঘণ্টার মধ্যে সহজ রিটার্ন
১০০% আসল পণ্য, মান যাচাইকৃত ও নিরাপদ প্যাকেজিং
পণ্যের বিবরণ
Indications
Folive is indicated for: During Pregnancy and Lactation For pregnant women to prevent neural tube defect in babies As a dietary supplement in adults and older people To prevent risk of spontaneous abortions In postmenopausal women to normalize homocystine, contributing to helping hot flashes, cardiovascular and bone health of aging women Folate deficiency caused by some medicines (e.g. those used to treat epilepsy such as phenytoin, phenobarbital and primidone) Folate deficiency caused by long term red blood cell damage or kidney dialysis In Depression, cognitive impairment, Dementia and Alzheimer's disease
Pharmacology
6s-5-methyltetrahydrofolate is a water-soluble vitamin B, which functions as a coenzyme or co-substrate in the synthesis of DNA and RNA and metabolism of amino acids. Deficiency is common during pregnancy which may lead to fetal malformations such as neural tube defects. Inadequate maternal folate status has also been associated with low infant birth weight, preterm delivery, and fetal growth retardation. Spina-bifi- da and anencephaly are the most common neural tube defects (NTDs). Folic acid supplementation before conception and during the first trimester has been shown to reduce the recurrence of NTDs in women. Supplementation is used to treat megaloblastic anemia during pregnancy. 68-5-methyltetrahydrofolate is the fourth generation folate derivatives, a new generation of folic acid derivative made up of (6S-5-methyltetrahydrofolate) and glucosamine salt which is readily active and has added advantage of higher bioavailability, safety and stability.
Dosage & Administration
1-2 Capsule daily or as directed by the physician.
Interaction
Folive may show possible drug interactions. Anticonvulsant action of phenytoin is antagonized by Folic Acid. Folate deficiency may result from increased loss of folate, as in renal dialysis and/or interference with metabolism (e.g., Folic Acid antagonists such as Methotrex- ate); the administration of anticonvulsants, such as diphenylhydantoin, primidone, and barbiturates; alcohol consumption and, especially alcoholic cirrhosis; and the administration of pyrimethamine and, nitrofurantoin. Taking Folate (Folive) along with amiodarone might increase the chances of sunburn, blistering, or rashes on areas of skin exposed to sunlight. Folate (Folive) might increase breaks down of phenobarbital leading to decrease the effectiveness of phenobarbital.
Contraindications
6s-5-methyltetrahydrofolate is contraindicated in patients with known hypersensitivity to any of the ingredients.
Side Effects
Folive is generally well-tolerated by the body. Gastrointestinal disturbances and hypersensitivity reactions have been reported rarely. However, the administration of high doses can cause the following: Gastrointestinal disorders: Anorexia, diarrhea, nausea, abdominal distension, and flatulence. Hypersensitivity reactions: Allergic reactions,comprising erythema,rash,pruritus,urticaria, and anaphylactic reactions (including shock).
Pregnancy & Lactation
Use in pregnancy is considered safely acceptable. Folic acid is actively secreted in breast milk. Supplementation in lactating women may be needed if poor nutritional habits lead to maternal deficiency and megaloblastic anemia. The American Academy of Pediatrics considers folic acid compatible with breast feeding.
Precautions & Warnings
Folic acid alone is inadequate therapy in the treatment of pernicious anemia and other megaloblastic anemias where Vitamin B12 is deficient. Folic acid in doses above 0.1 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations progress. While prescribing this nutritional supplement for pregnant women, nursing mothers or for women prior to conception, their medical condition and any drugs, herbs and/or supplements consumption should be considered.
Overdose Effects
In case of accidental over dosage, call a doctor or refer to healthcare facility immediately.
Therapeutic Class
Herbal and Nutraceuticals
Storage Conditions
Store at below 25°C in a dry place protected from light. Keep out of reach of children.